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ZWIĄZKI DO INHIBICJI ENZYMÓW PROTEASOMU
专利权人:
Inc.;Onyx Therapeutics
发明人:
SMYTH, MARK S.,LAIDIG, GUY J.
申请号:
PL16166492
公开号:
PL3101026T3
申请日:
2005.08.08
申请国别(地区):
PL
年份:
2018
代理人:
摘要:
Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsin-like activity of the 20S proteasome may be selectively inhibited with the inventive compounds. The peptide-based compounds include an epoxide or aziridine, and functionalization at the N-terminus. Among other therapeutic utilities, the peptide-based compounds are expected to display anti-inflammatory properties and inhibition of cell proliferation.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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