The invention relates to an ultrasound system for imaging a volumetric region (132) comprising a region of interest (82'). The system comprises a probe (10) for intracavity imaging; a beamformer coupled to the array and adapted to control ultrasound beam steering and provide ultrasound image data of the volumetric region; an image processor responsive to the ultrasound image data, based on which it is adapted to produce an ultrasound image; and a region of interest (ROI) identifier enabling to identify a region of interest on the basis of the ultrasound image data, and which identifier is adapted to generate identification data indicating the region of interest within the volumetric region; wherein the ultrasound system is configurable by a plurality of use cases in response to respective identifiers of said use cases, each use case being associated with a particular intracavity imaging procedure and comprising an anatomical model for said intracavity imaging procedure; and wherein the ROI identifier is configurable by the respective anatomical models of said use cases. A method of configuring such an ultrasound system is also disclosed.