Catherine M. Rohloff,Guohua Chen,Zhongli Ding,Stephen A. Berry,Latha P. Narayanan,Michael A. Desjardin
申请号：
US13789593
公开号：
US20140088013A1
申请日:
2013.03.07
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Formulations and methods are provided for improving the stability upon exposure to aqueous media of polypeptides present in non-aqueous suspension vehicles. In particular aspects of the invention, formulations are provided that comprise a complex of a metal ion and a polypeptide suspended in a non-aqueous, biocompatible suspension vehicle. Aggregation of individual polypeptide molecules is reduced when aqueous media is introduced to such formulations, serving to stabilize the polypeptide.
