Substituted pyrimidinyl and pyridinyl-pyrrolopyridinones, process for their preparation and their use as kinase inhibitors

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专利权人:

NERVIANO MEDICAL SCIENCES S.r.l

发明人:

Maria Menichincheri,Mauro Angiolini,Jay Aaron Bertrand,Michele Caruso,Paolo Polucci,Francesca Quartieri,Barbara Salom,Matteo Salsa,Fabio Zuccotto

申请号：

US14647940

公开号：

US09604980B2

申请日:

2013.10.31

申请国别(地区):

US

年份:

2017

代理人:

摘要：

The present invention relates to substituted pyrimidinyl- and pyridinylpyrrolopyridinone compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular RET family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions containing these compounds.

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