595506 Disclosed herein is a compound of Formula (I), wherein the variables are defined in the specification, and the use thereof in the treatment of a chronic neurodegenerative disease such as Alzheimers Disease, Parkinsons Disease, progressive supranuclear palsy, subacute panencephalitic parkinsonism, postencephalitic parkinsonism, dementia puglistica, guan-parkinsonial dementia complex, Picks disease, corticobasal degeneration, frontotemporal dementia with parkinsonism, Huntingtons disease, AIDS associated dementia, amyotrophic lateral sclerosis, and multiple sclerosis, or a neurotraumatic disease, such as acute stroke, mood disorders such as schizophrenia and bipolar disorders, promotion of functional recovery post stroke, cerebral bleeding, hair loss, obesity, atherosclerotic cardiovascular disease, hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, cancer, leukopenia, Downs syndrome, Lewy body disease, inflammation and immunodeficiency. Exemplary compounds include: 3-(6-chloro-2-cyclopentyl-2H-pyrazolo[3,4-d]pyrimidin-4-yl)-2-oxo-2,3-dihydro-1H-indole-5-carbonitrile 3-{ 6-[bis-(2-methoxyethyl)amino]-2-cyclopentyl-2H-pyrazolo[3,4-d]pyrimidin-4-yl} -2-oxo-2,3-dihydro-1H-indole-5-carbonitrile 2-oxo-3-[2-propyl-6-(2-pyridin-2-yl-ethylamino)-2H-pyrazolo[3,4-d]pyrimidin-4-yl]-2,3-dihydro-1H-indole-5-carbonitrile and 5-chloro-3-[2-cyclopentyl-6-((R)-2-hydroxy-propylamino)-2H-pyrazolo[3,4-d]pyrimidin-4-yl]-1,3-dihydro-indol-2-one.
