The cancer, the especially lung cancer or the esophagus cancer remedy and/or features the manner in order to prevent one of the TBC1D7 gene or by prescribing the constituent, the vector or the cell which include two these chain numerators or that kind of two these chain numerators for multiple this invention, in regard to the role which is carried out by the TBC1D7 gene in the cancer, the especially lung cancer or the esophagus cancer, or carcinogenesis. In addition as for this invention, one which is chosen from midst of TBC1D7 or the multiple excessive revelation genes were used, diagnosis or the lung cancer of the lung, especially NSCLC or also manner for evaluating the convalescence of the patient who possesses the SCLC or esophagus cancer/decision makes feature. Because of the object, as for TBC1D7 there is a possibility of being useful as the new bio marker regarding the lung cancer or the esophagus cancer. In addition, it discloses also the manner which identifies the chemical compound in order it remedies or to prevent the lung cancer or the esophagus cancer, or the inside one of TBC1D7 in the lung cancer or the esophagus cancer or as collimating mark using those influences which it causes to multiple excessive revelations.本発明は、癌、特に肺癌もしくは食道癌、又は発癌においてTBC1D7遺伝子によって果たされる役割に関し、癌、特に肺癌又は食道癌をTBC1D7遺伝子の1つ又は複数に対する二本鎖分子、又はそのような二本鎖分子を含む組成物、ベクターもしくは細胞を投与することによって治療及び/又は予防するための方法を特徴とする。本発明はまた、TBC1D7の中から選択された1つ又は複数の過剰発現遺伝子を用いた、肺の診断、又は肺癌、特にNSCLCもしくはSCLC又は食道癌を有する患者の予後の評価/判定のための方法も特徴とする。その目的のために、TBC1D7は肺癌又は食道癌に関する新規バイオマーカーとして役立つ可能性がある。また、肺癌又は食道癌におけるTBC1D7のうち1つ又は複数の過剰発現に及ぼすそれらの影響を指標として用いて、肺癌又は食道癌を治療又は予防するための化合物を同定する方法も開示する。
