INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY
发明人:
KIM, Yong-Hee,김용희,LIM, Kwang-Suk,임광석
申请号:
KRKR2013/006260
公开号:
WO2014/010985A1
申请日:
2013.07.12
申请国别(地区):
WO
年份:
2014
代理人:
摘要:
The present invention relates to a method for introducing intracellular protein in a highly efficient fashion. More specifically, the present invention relates to: a method for markedly improving the efficiency of intracellular introduction and maintenance of a biological functional material such as a protein, nucleic acid or drug by using a specific short mitochondria target peptide and sMTS and a fusion composition used therewith.La présente invention concerne un procédé dintroduction dune protéine intracellulaire dune façon hautement efficace. Plus particulièrement, la présente invention concerne : un procédé pour lamélioration de façon marquée de lefficacité de lintroduction et de la conservation intracellulaires dune matière fonctionnelle biologique, telle quune protéine, un acide nucléique ou un médicament, par lutilisation dun court peptide cible de mitochondrie spécifique et sMTS et une composition de fusion utilisée avec celui-ci.본 발명은 높은 효율로 세포내 단백질을 도입하는 방법에 관한 것으로, 보다 상세하게는 특정의 짧은 미토콘드리아 표적 펩타이드, sMTS를 이용하여 단백질, 핵산, 약물 등과 같은 생체 기능성 물질의 세포내 도입 및 유지 효율을 현저히 향상시키기 위한 방법 및 이에 사용되는 융합체 조성물에 관한 것이다.