INJE UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人:
CHOI, GUANG JIN,최광진,CHUN, NAN HEE,천난희,LEE, HEA EUN,이혜은,LEE, MIN JEONG,이민정,WANG, IN CHUN,왕인천
申请号：
KR1020110146131
公开号：
KR1020130077429A
申请日:
2011.12.29
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: An indomethacin co-crystal including indomethacin (IMC) and saccharin is provided to remarkably improve the solubility and the leaching rate of indomethacin in comparison with the existing indomethacin.CONSTITUTION: An indomethacin co-crystal comprises indomethacin and saccharin. The mole ratio of the indomethacin and the saccharin is 1:1 through 1:2. A manufacturing method of the co-crystal including the indomethacin and the saccharin comprises: (i) a step of manufacturing a solution by dissolving the indomethacin and the saccharin in the selected solvent from a group comprising ethyl acetate, methyl acetate, ethanol, methanol, and acetone (ii) a step of adding anti-solvent to the solution of (i) step and (iii) a step of obtaining the crystallized particle by stirring and vacuum filtering the solution of (ii) step. The co-crystal containing the indomethacin and the saccharin is included in a pharmaceutical composition with the pharmaceutically acceptable diluent or carrier.COPYRIGHT KIPO 2013본 발명은 인도메타신 공결정, 이의 제조 방법 및 이를 포함하는 약학적 조성물에 관한 것으로서, 더욱 상세하게는 인도메타신 및 사카린을 포함하는 공결정, 이의 제조 방법 및 이를 포함하는 약학적 조성물에 관한 것이다. 본 발명에 의한 인도메타신 및 사카린을 포함하는 공결정은 기존 인도메타신에 비해 인도메타신의 용해도와 용출 속도를 크게 향상시킬 수 있다.
