A sterilization device includes: a charged fine water droplet supplying unit and a plasma generating unit, wherein the charged fine water droplet supplying unit and the plasma generating unit are provided on a wall surface of a wind channel in order of the charged fine water droplet supplying unit and the plasma generating unit from an upper stream in a direction in which air flows, the plasma generating unit includes a charged fine water droplet supplying part and a plasma generator, the charged fine water droplet supplying part includes a high-voltage power supply, an earthed electrode, and an electrode to which moisture is supplied by a water feeding unit, a negative high voltage with respect to the earthed electrode being applied to the electrode supplied with moisture, the plasma generator includes a pair of plasma generating electrodes and a high-frequency power supply, the plasma generating electrodes being covered by a dielectric substance and being provided in the same plane with the dielectric substance, and the air is converted into plasma and emitted when voltage is applied to the plasma generating electrodes by the high-frequency power supply. Thus, it is possible to make a strong sterilization effect and control of a toxic substance compatible.