The present invention relates to a kind of disulfates and preparation method thereof of jak kinase inhibitor. More particularly it relates to as shown in formula (I) (3aR,5s,6aS)-N- (methoxyl group -1 3-,2,4- thiadiazoles -5- bases) -5- (methyl (7H- pyrrolo-es [2,3-d] pyrimidine-4-yl) amino) hexahydro cyclopentano [c] pyrroles -2 (1H)-formamide disulfate and its preparation method and application. The disulfate as shown in formula (I) can be work perfectly well as jak kinase inhibitor application what clinic, for treating rheumatism and rheumatoid arthritis.本發明涉及一種JAK激酶抑制劑的硫酸氫鹽及其製備方法。更具體地，本發明涉及如式(I)所示的(3aR,5s,6aS)-N-(3-甲氧基-1,2,4-噻二唑-5-基)-5-(甲基(7H-吡咯并[2,3-d]嘧啶-4-基)氨基)六氫環戊并[c]吡咯-2(1H)-甲酰胺硫酸氫鹽及其製備方法和用途。如式(I)所示的硫酸氫鹽可很好地作爲JAK激酶抑制劑應用於臨床，用來治療風濕及類風濕性關節炎。
