COMPOSITION FOR PREVENTION AND TREATMENT OF MUSCULAR DISEASES OR FOR IMPROVEMENT OF MUSCLE FUNCTION CONTAINING 3,5-DICAFFEOYLQUINIC ACID OR CHRYSANTHEMUM EXTRACT
Cosmax NBT, Inc.;Industry-Academic Cooperation Foundation, Yonsei University;Cosmax NS, Inc.
发明人:
Jae Kwan HWANG,Jun Gon YUN,Mi Bo KIM,Chang Hee KIM,Joon Hyung LEE,Do Wan KWON,Su Young CHOI,Jin Hak KIM,Ji Hwan JANG,Jeong Ho GEUM,Min Son KWEON
申请号：
US16474528
公开号：
US20200009208A1
申请日:
2017.11.30
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relates to a composition for preventing or treating a muscle disorder, which includes a chrysanthemum extract or 3,5-dicaffeoylquinic acid as an active ingredient, and specifically, it may be used to reduce mRNA expression of atrogin-1 and MuRF1, which are main biomarkers involved in muscle protein degradation and increase mRNA expression of the mTOR protein, which is a main biomarker involved in muscle protein formation, and myogenin and MyoD, which are biomarkers related to muscle differentiation, thereby reducing muscle loss, and thus the chrysanthemum extract or 3,5-dicaffeoylquinic acid can be used in prevention and treatment of a muscle disorder, or improvement in muscle function. In addition, the chrysanthemum extract or 3,5-dicaffeoylquinic acid increases the activity of SIRT1 and PGC-1α, which are the main biomarkers involved in exercise performance, thereby excellently enhancing exercise performance. In addition, the present invention is a natural substance and may be safely used without a side effect, and therefore may be used as a medication, food or a cosmetic.
