Mutéines de la région acide du domaine extracellulaire de FGFR.

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专利权人:

Five Prime Therapeutics; Inc.

发明人:

申请号：

EP09791148.1

公开号：

EP2318529B1

申请日:

2009.08.04

申请国别(地区):

EP

年份:

2017

代理人:

摘要：

Fibroblast growth factor receptor (FGFR) extracellular domain (ECD) acidic region muteins that have been engineered to exhibit decreased tissue binding by increasing the number of acidic amino acid residues within the D1-D2 linker region are provided. Polynucleotides encoding FGFR ECD acidic region muteins are also provided. Methods of making FGFR ECD acidic region muteins, and methods of using such molecules to treat proliferative disorders, including cancers, disorders of angiogenesis, and macular degeneration, are also provided.

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