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Peptides having pharmacological activity for treating disorders associated with altered cell migration, such as cancer
专利权人:
Maria Vincenza Carriero;Vincenzo Pavone;Mario De Rosa
发明人:
Maria Vincenza Carriero,Mario De Rosa,Vincenzo Pavone
申请号:
US12376465
公开号:
US08354374B2
申请日:
2007.07.19
申请国别(地区):
US
年份:
2013
代理人:
摘要:
Peptides and their functionally equivalent derivatives, in salt form or non-salt form, effective in the treatment and prevention of tumor, with the general formula L1-X1-X2-X3-X4, wherein: L1 is H, or acyl, or any natural or non-natural amino acid; X2 is any natural or non-natural amino acid, optionally N-alkylated and/or Cα-alkylated; X4 is any natural or non-natural hydrophobic amino acid, optionally Cα-alkylated and/or amidated at the C-terminal end, or any hydrophobic amino alcohol, or a hydrophobic gem-diamine, optionally N′-alkylated or N′-acylated.
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