NIRAPARIB SUSTAINED AND CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION AND USE THEREOF

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专利权人:

Yong Gan;Bingxue Meng;Yan Liu;Chunliu Zhu;Shiyan Guo

发明人:

Yong Gan,Bingxue Meng,Yan Liu,Chunliu Zhu,Shiyan Guo

申请号：

US16442049

公开号：

US20190290629A1

申请日:

2019.06.14

申请国别(地区):

US

年份:

2019

代理人:

摘要：

Provided are a niraparib sustained and controlled release pharmaceutical composition and use thereof. The sustained and controlled release pharmaceutical composition contains dissolution-improved niraparib and a matrix polymer used for regulating release rate； the steady-state plasma concentration trough value Cmin,ss of the pharmaceutical composition is 0.5-4 μM； the steady-state plasma concentration peak value Cmax,ss is 0.8-6 μM.

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