YANG, PAN CHYR,杨泮池,楊泮池,LAI, WEI YUN,赖薇云,賴薇云,WANG, JEN WEI,王人纬,王人緯
申请号:
TW107147202
公开号:
TW201943853A
申请日:
2018.12.26
申请国别(地区):
TW
年份:
2019
代理人:
摘要:
Nucleic acid aptamers that bind to tumor necrosis factor alpha (TNF). Also provided herein are pharmaceutical compositions comprising such anti-TNF aptamers and methods for the using the same for therapeutic and diagnostic applications, for example, alleviating liver injury and monitoring presence of TNF in vivo or in vitro.本發明涉及與腫瘤壞死因子α(TNF)結合的核酸適配體。本發明進一步提供包含此等抗TNF適配體的醫藥組成物,以及將其用於治療和診斷應用的方法,例如,減輕肝損傷和於體內或體外監測TNF的存在。