isolated monoclonal antibody or antigen-binding fragment thereof that binds to cd8, pharmaceutical composition, nucleic acid molecule, expression vector, host cell, antibody conjugate, methods for imaging cd8-expressing tissue to treat a subject having a solid tumor, to predict a positive response to an anti-tumor therapy, to monitor a tumor response in a subject to an anti-tumor therapy, to predict or monitor the effectiveness of anti-tumor therapy, and to monitor the presence of t cells in a tumor over time, and, compound.
DANGSHE MA,GAVIN THURSTON,JASON T. GIURLEO,RICHARD TAVARE,WILLIAM OLSON
申请号：
BR112020001360
公开号：
BR112020001360A2
申请日:
2018.07.23
申请国别(地区):
BR
年份:
2020
代理人:
摘要：
anti-cd8 antibodies, radiolabeled anti-cd8 antibodies, fluorescence-labeled anti-cd8 antibodies are provided in this document and their use in imaging. methods for detecting the presence of cd8 proteins in a subject or sample are included.são fornecidos neste documento anticorpos anti-cd8, anticorpos anti-cd8 radiomarcados, anticorpos anti-cd8 marcados com fluorescência e uso destes na geração de imagens. são incluídos métodos de detecção da presença de proteínas cd8 em um sujeito ou amostra.
