Disclosed are a zero point calibration method and apparatus for a pressure sensor of an anesthesia machine. The method comprises: performing zero point calibration on an airway pressure sensor of the anesthesia machine (110)； restarting and carrying out startup self-testing (120)； and judging whether pressure change values of the airway pressure sensor and an ambient pressure sensor are the same, and if the values are the same, performing zero point calibration on the ambient pressure sensor according to a zero point of the airway pressure sensor (130). By the method of the invention, zero point calibration for a pressure sensor of an anesthesia machine can be realized via a simple operation, thereby avoiding errors in operation.
