Ada Yonath,Chen Davidovich,Ella Zimmerman,Anat Bashan,Tamar Auerbach,Matthew Belousoff,Liqun Xiong,Dorota Klepacki,Alexander S. Mankin
申请号：
US13519862
公开号：
US20120316106A1
申请日:
2010.12.29
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Improved antibiotic analogs, and synergistic combinations of antibiotics designed based on structural crystallographic analysis, are provided as well as pharmaceutical compositions that include these improved analogs and synergistic combinations, along with methods for their production and use. The synergistic combinations target neighboring sites in the ribosome demonstrating the importance of the corresponding ribosomal sites for development of clinically-relevant synergistic antibiotics.
