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1-substituted tetrahydroisoquinoline compound
专利权人:
ASTELLAS PHARMA INC.
发明人:
OGIYAMA, TAKASHI,SHISHIKURA, JUN-ICHI,YONEZAWA, KOICHI,OKADA, HIDETSUGU,INOUE, MAKOTO,YOKOYAMA, KAZUHIRO,KAKIMOTO, SHUICHIROU,YAMAKI, SUSUMU
申请号:
AU2008254061
公开号:
AU2008254061B2
申请日:
2008.05.20
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
Provided is a compound useful as an N-type Ca 2+ channel blocker. As a result of intensive studies of compounds having an action of blocking N-type Ca 2+ channels, the present inventors found that a tetrahydroisoquinoline compound of the present invention having a substituent at the 1-position has an action of blocking the N-type Ca 2+ channels, an antinociceptive pain action, an antineuropathic pain action, an abdominal pain-inhibitory action and an opioid-induced constipation-improving action, and the present invention has been completed based on these findings. The compound of the present invention can be used as a pharmaceutical composition for preventing and/or treating various pains such as neuropathic pain and nociceptive pain, headaches such as migraine and cluster headache, central nervous system diseases such as anxiety, depression, epilepsy, cerebral stroke and restless legs syndrome, abdominal symptoms such as abdominal pain and abdominal distension, stool abnormalities such as diarrhea and constipation, digestive system diseases such as irritable bowel syndrome, urinary system diseases such as overactive bladder and interstitial cystitis, etc.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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