ANTIGÈNE DU VIRUS DE LA GRIPPE AVIAIRE ET PROCÉDÉ D'IMMUNISATION DE RAPPEL POUR UN VACCIN CONTRE LA GRIPPE AVIAIRE EN COMBINAISON AVEC UN ADJUVANT MUQUEUX QUI EST EFFICACE PAR ADMINISTRATION ORALE

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专利权人:

LTD.;KITASATO DAIICHI SANKYO VACCINE CO.

发明人:

MIYOSHI, YUKIHIRO,ITO, AKIRA,SUSA, KENTARO,HIMENO, NAOMI,GOTANDA, TORU

申请号：

EP09808225

公开号：

EP2329845A4

申请日:

2009.08.13

申请国别(地区):

EP

年份:

2013

代理人:

摘要：

When ELISA antibody titer dropped in chickens intramuscularly inoculated with an oil vaccine, recombinant HA and NP antigens prepared using gene recombinant technology were orally administered in combination with synthetic oligo CpG as a mucosal adjuvant to the chickens. Even when the immune response induced with the oil vaccine was impaired, the antibody titer was re-induced by orally administering the recombinant HA and NP antigens, and synthetic CpG-ODN in combination.

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