Christopher A. FRENCH,Peter M. HOWLEY,Erica Marlene WALSH MICHEL,Shaila RAHMAN,Simone KUHNLE
申请号：
US15114020
公开号：
US20170007595A1
申请日:
2015.01.23
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to the use of NSD3i inhibitors for the treatment of cancer. In particular, the present invention relates to methods, kits and compositions comprising NSD3 inhibitors to treat cancers dependent on NSD3, in particular subjects with NUT midline carcinoma (NMC) and subjects with NSD3/NUT or BRD4/NUT or BRD3/NUT fusion genes, as well as subjects with BRD4-dependent (but NUT-independent cancers). The present invention also relates to methods, kits and compositions comprising BET inhibitors for the treatment of subjects with NSD3/NUT fusion genes. Other aspects of the invention relate to assays and methods to identify an inhibitor of NSD3 which disrupts or decreases the interaction of the NSD3 protein with the ET do main of BRD4.
