Eyal SHIMONI,Ory RAMON,Isaiah J. KOPELMAN,Shimon MIZRAHI,Nir SALZMAN,Yaakov NAHMIAS,Aharon OREN
申请号：
US14865516
公开号：
US20160008290A1
申请日:
2015.09.25
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Enteric coated capsules or tables for oral delivery of a protein, polypeptide or peptide drug, in particular for oral delivery of insulin, are provided, comprising microparticles of the protein, polypeptide or peptide drug, microparticles of a protease inhibitor and, optionally, microparticles of an absorption enhancer. The protease inhibit and the absorption enhancer may be together in the same microparticles. The microparticles of each component are embedded in an enteric polymer matrix. The enteric coated tablet or capsule of the invention enables fast release of the protein, polypeptide or peptide drug at different times at desired loci in the gastrointestinal tract.
