Medical devices for local bioactive delivery are described. A medical device has an elongate shaft extending between proximal and distal ends and a distal portion that defines a pigtail. A balloon is disposed on the elongate shaft proximal to the pigtail. The elongate shaft defines a first working lumen with a distal opening disposed between the balloon and the pigtail, and a second working lumen with a distal opening disposed distal to the first working lumen distal opening. Methods of using medical devices are also described.
