SOONCHUNHYANG UNIVERSITY INDUSTRY ACADEMY COOPERATION FOUNDATION
发明人:
SONG, KEON HYOUNG,송건형,SONG, KEON HYOUNGKR
申请号：
KR1020140080608
公开号：
KR1014707930000B1
申请日:
2014.06.30
申请国别(地区):
KR
年份:
2014
代理人:
摘要：
The present invention relates to an absorption enhancer which can improve a function of promoting mucosal permeability of peptide and significantly improve bio-availability of a drug which is administered with the enhancer by changing a terminal of a carboxylic group of peptide. The purpose of the present invention is to provide peptide as an absorption enhancer which helps in vivo absorption of an active ingredient. To this end, the present invention has homogeny with an amino acid sequence represented by the sequence number 1, or the sequence number 1, and provides peptide in which a carboxylic group -COOH of leucine located on a terminal of the amino acid sequence is changed into -CONH_2.본 발명은 흡수촉진제로서 펩타이드의 카르복실기의 말단을 변형시켜 펩타이드의 점막 투과 촉진 기능을 향상시켜 함께 투여되는 약물의 생체이용률을 현저히 향상시킬 수 있다.
