DONALD, Alastair,MCDERMOTT, Joanne,PATEL, Sanjay,MOFFAT, David
申请号：
ES11726470
公开号：
ES2587256T3
申请日:
2011.06.10
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
Compound which is (a) a phenylamide derivative of the formula (I) or a tautomer thereof, or (b) a pharmaceutically acceptable salt, Nóxide, hydrate or solvate thereof: ** Formula ** wherein: - R1 and R3 are hydroxy； - R2, R4 and R5 are the same or different and represent hydrogen or halogen atoms or C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, hydroxy, cyano, nitro or -NR'R " wherein R 'and R "are the same or different and represent hydrogen or unsubstituted C1-4 alkyl, provided that no more than two of R2, R4 and R5 are cyano or nitro； - or: (i) R6 is selected from C1-4 alkyl and R7 represents -CR8R9-A wherein R8 and R9 are the same or different and represent a hydrogen or halogen atom or a C1-4 alkyl group, C2 alkenyl- 4, C1-4 alkoxy, hydroxy or -NR'R "where R 'and R" are the same or different and represent hydrogen or unsubstituted C1-4 alkyl, and A represents a phenyl ring or a heteroaryl group of 5 or 6 members and replaced with a group W； or (ii) R6 and R7, together with the nitrogen atom to which they bind, form a 5- or 6-membered heterocyclyl group that is either (a) unbound, or (b) fused to a phenyl ring or a 5 or 6-membered heteroaryl group, and where either the heterocyclyl group, when fused, the heterocyclyl group or the phenyl ring or the heteroaryl group to which it is fused, is substituted with a group W； - W represents a group -Alk1-R； - Alk1 represents a bond, a C1-4 alkylene group or a group - (C1-4 alkylene) -NR '- (C1-4 alkylene) - wherein R' represents hydrogen or C1-4 alkyl； - R represents a group of the formula (X) or (Y): ** Formula ** - R10, when present, represents a hydrogen atom or a C1-4 alkyl group； - Alk2 represents a group of formula -C (R12) (R13) - when R is of formula (X), or -C (R12) - when R is of formula (Y), where R12 and R13 are the same or different and represent hydrogen or the α substituents of a compound of α-substituted glycine or α, α-disubstituted glycine or glycine ester； - a D ring, when present, is a 5- or 6-
