Compounds of formula I modulate JNK:whereinX1 and X2 are each simultaneously N or CH；X3 is CH—R2 or N—SO2R, where R is lower alkyl；R1 is aryl or heteroaryl, substituted with 0-3 lower alkyl radicals；R2 iswhere R3 is H, lower acyl, or an amino acid,or a pharmaceutically acceptable salt thereof.
