There is a need for a new antibiotic having a novel mechanism of action, which exhibits strong antibacterial activity not only against sensitive bacteria, but also against resistant bacteria thereof, and at the same time possess excellent solubility and safety profile amenable to human use.As a result of intensive research, the present inventors have found that N-phosphonoxymethyl prodrugs of hydroxyalkyl thiadiazole derivatives represented by general formula (I), a regioisomer, a stereoisomer, or a pharmaceutically acceptable salt thereof possess excellent solubility and safety profile for use in human for the treatment of bacterial infectious diseases.有需要一種具有新穎作用機制之新穎抗生素，其不僅對於敏感細菌展現出強抗菌活性，對於其之抗藥性細菌亦展現出強抗菌活性，且同時具有可受人類使用之優異的可溶性及安全性概貌(safety profile)。作為深入研究的結果，本發明人等發現一種通式(I)所表示的羥烷基噻二唑衍生物之N-膦醯基氧基甲基前驅藥、其位置異構物(regioisomer)、立體異構物、或醫藥上可接受的鹽，其在用於細菌感染性疾病之治療時具有於人類使用之優異的可溶性及安全性概貌。
