BAE, SUNG MIN,裴城敏,IM, DAE SEONG,任大成,KIM, MIN YOUNG,金玟永,LIM, CHANG KI,林昌基,JUNG, SUNG YOUB,郑圣烨,鄭聖燁,KWON, SE CHANG,权世昌,權世昌
申请号：
TW100101721
公开号：
TWI417104B
申请日:
2011.01.18
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
Disclosed is a liquid formulation which allows long-acting EPO conjugates, that have improved in vivo duration and stability, to be stable when stored for a long period of time. It comprises a stabilizer composition characterized by buffer and mannitol. Being free of human serum albumin and other potential factors harmful to the body, the liquid formulation is free of concerns about viral infections and guarantees excellent storage stability to long-acting EPO conjugates.本發明揭示一種液態劑型，此液態劑型使具有增進之活體內持續時間及穩定性之長效型EPO共軛物得以貯存長時間仍相當穩定。其包含特徵為緩衝劑及甘露糖醇之穩定劑組成物。於無人類血清白蛋白及對人體有害之其他潛在因子下，此液態劑型免於擔心病毒感染及確保對長效型EPO共軛物之優異貯存穩定性。
