SAXTY, Gordon,BERDINI, Valerio,MURRAY, Christopher William,GRIFFITHS-JONES, Charlotte Mary,VICKERSTAFFE, Emma,BESONG, Gilbert Ebai,CARR, Maria Grazia
申请号：
ES08806556
公开号：
ES2559685T3
申请日:
2008.10.10
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of the formula (I): ** Formula ** wherein it represents a single or double bond, such that within the 5-member ring system, at least one bond is a double bond； Ring A may be optionally substituted by 1, 2 or 3 Ra groups； R4 and R5 independently represent hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, C1-6 alkanol, C1-6 haloalkyl, - (CH2) n-NRxRy, - (CH) 2) s-COORz, - (CH2) nO- (CH2) m-OH, - (CH2) n aryl, - (CH2) nO-aryl, - (CH2) n-heterocyclyl or - (CH2) nO-heterocyclyl wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, aryl and heterocyclyl groups may be optionally substituted by 1, 2 or 3 Ra groups； Rx, Ry and Rz independently represent hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkanyl, -COO C 1-6 alkyl, hydroxy, C 1-6 alkoxy, C 1-6 haloalkyl, -CO - (CH2) n- C1-6 alkoxy, C1-6 aminoalkyl, C3-8 cycloalkyl or C3-8 cycloalkenyl； R2 represents a group -CONR7R8 or -CORx； R7 and R8 independently represent hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, aryl, heterocyclyl or R7 and R8 together with the nitrogen atom to which they are attached they can form a nitrogen-containing heterocyclyl ring, wherein said C1-6 alkyl, aryl and heterocyclyl groups may be optionally substituted by 1, 2 or 3 Rb groups； Ra represents halogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, -ORx, -O- (CH2) n-ORx, C1-6 haloalkyl, C1-haloalkoxy -6, alkanol C1-6,>； = O,>； = S, nitro, Si (Rx) 4, - (CH2) s-CN, -S-Rx, -SO-Rx, -SO2- Rx, -CORx, - (CRxRy) s-COORz, - (CH2) s-CONRxRy, - (CH2) s-NRxRy, - (CH2) s-NRxCORy, - (CH2) s-NRxSO2-Ry, - (CH2) sNHSO2-NRxRy, -OCONRxRy, - (CH2) s-NRxCO2Ry, -O- (CH2) s-CRxRy- (CH2) t-ORz or - (CH2) s-SO2NRxRy； Rb represents a Ra group or a -Y-carbocyclic or -Z-heterocyclyl group wherein said carbocyclic and heterocyclyl groups may be optionally substituted by 1, 2 or 3 Ra groups； Y and Z indepe
