LERCHEN, HANS-GEORG,REBSTOCK, ANNE-SOPHIE,MARX, LEO,JOHANNES, SARAH ANNA LIESA,STELTE-LUDWIG, BEATRIX,DIETZ, LISA,TERJUNG, CARSTEN,MAHLERT, CHRISTOPH,GREVEN, SIMONE,SOMMER, ANETTE,BERNDT, SANDRA,WAGNER, SARAH
申请号：
CA3018630
公开号：
CA3018630A1
申请日:
2017.03.21
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The invention relates to novel prodrugs or conjugates of the general formula (Ia), in which cytotoxic active agents such as kinesin spindle protein inhibitors, for example, are masked by mean of groups cleavable by legumain, thus releasing the active agent. The invention further relates to the use of said prodrugs or conjugates for treating and/or preventing diseases, and to the use of said prodrugs or conjugates for producing drugs for treating and/or preventing diseases, in particular hyperproliferative and/or angiogenic diseases such as cancers, for example.
