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противомикробный drug itself in the form of быстрорастворимых шипучих pills to make solution for local and external use and method of obtaining it
专利权人:
ОТКРЫТОЕ АКЦИОНЕРНОЕ ОБЩЕСТВО "АВЕКСИМА"
发明人:
Елена Васильевна,Андрей Александрович,Даниил Евгеньевич
申请号:
EA201700201
公开号:
EA201700201A1
申请日:
2017.04.11
申请国别(地区):
EA
年份:
2018
代理人:
摘要:
the invention relates to the chemical pharmaceutical industry and the противомикробного pharmaceutical preparation for veterinary and medical application in the form of шипучих pillsused for the preparation of the solution for the local and external use, as well as ways of obtaining it.the technical result of the invention is to improve the strength of improving the appearance of the tablets (absence of a beveling, налипов, натиров side surface).improving the stability of the quality and increase the expiration date) to 25 years, through the optimization of the choice of the ratio of the acid and basic components газообразующей mixture and use of поливинилпирролидона to 25; a reduction in the number of operations.the reduction of the time for cleaning the press tool.the technical result is achieved bywhat противомикробный drug itself in the form of быстрорастворимых шипучих pills to make solution for local and external use contains the active ingredient фурац llyn (нитрофураl) and excipients: sodium chloride, газообразующую mixture, acidity regulator, lube, поливинилпирролидон to 25 with a total mass of 800 to 2400 mg tablets and next of компон ентов,in the mas. per cent, nitrofural - 0.8 - 2.5; sodium chloride - 6.0 - 9.0; газообразующая mixture is 56,18 - 75,95; acidity regulator is 7.25 - 27.5; lube - 1.0 to 6.0; поливинилпирролидон to - 25 - 1.0 to 4.0.in addition, газообразующая mixture consists of organic acid and its stereoisomers and гидрокарбоната sodium.in the composition, as a regulator of acidity using sodium carbonate, as well as the lubricant using polyethylene glycol.also the technical result is achieved bywhat a way to obtain противомикробного pharmaceutical preparation in the form of быстрорастворимых шипучих pills to make solution for local and external use includes the following the governing stage: preдварительное grinding componentsthe average particle size which is greater than 60 mesh; mixing the dry components and their granulation, 10% to 25
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