COMPOSITIONS AND METHODS FOR TREATMENT OF DISEASES AND CONDITIONS EMPLOYING ORAL ADMINISTRATION OF SODIUM PENTOSAN POLYSULFATE AND OTHER PENTOSAN POLYSULFATE SALTS
URIGEN PHARMACEUTICALS, INC.;Christopher P. MEENAN;C. Lowell PARSONS;Michael GOLDBERG
发明人:
C. Lowell PARSONS,Michael GOLDBERG,Christopher P. MEENAN
申请号：
US15121312
公开号：
US20170189443A1
申请日:
2015.02.24
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention is directed to a pharmaceutical composition comprising: (1) a therapeutically effective quantity of sodium pentosan polysulfate； (2) a quantity of a penetration enhancer sufficient to improve the bioavailability of the sodium pentosan polysulfate； and (3) optionally, a pharmaceutically acceptable carrier and to methods for the oral administration of sodium pentosan polysulfate with improved bioavailability for the treatment of interstitial cystitis and other urinary tract diseases and conditions. Such compositions and methods allow the administration of sodium pentosan polysulfate at lower dosages to reduce the frequency and severity of side effects.
