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AGENTS CYTOTOXIQUES AMELIORES CONTENANT DE NOUVEAUX MAYTANSINOIDES
专利权人:
IMMUNOGEN; INC.
发明人:
申请号:
EP04750945.0
公开号:
EP1651162B1
申请日:
2004.05.20
申请国别(地区):
EP
年份:
2015
代理人:
摘要:
New thiol and disulfide-containing maytansinoids bearing a substitution on the ±-carbon atom bearing the sulfur atom are disclosed. Also disclosed are methods for the synthesis of these new maytansinoids and methods for the linkage of these new maytansinoids to cell-binding agents. The maytansinoid-cell-binding agent conjugates are useful as therapeutic agents, which are delivered specifically to target cells and are cytotoxic. These conjugates display vastly improved therapeutic efficacy in animal tumor models compared to the previously described agents.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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