AKOPIAN, VIOLETTA,MINOMI, KENJIRO,NIITSU, YOSHIRO,PAYNE, JOSEPH E.,KNOPOV, VICTOR,WITTE, RICHARD P.,AHMADIAN, MOHAMMAD,PERELMAN, LOREN A.,TANAKA, YASUNOBU,FEINSTEIN, ELENA,AVKIN-NAHUM, SHARON,KALINSKI
申请号：
CA2836925
公开号：
CA2836925A1
申请日:
2012.06.08
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
What is described are pharmaceutical compositions comprising a double-stranded nucleic acid molecule comprising a sense strand and an antisense strand wherein the sense and antisense strands are selected from the oligonucleotides described as SERPINH1_2 (SEQ ID NOS: 60 and 127), SERPTNHl_45a (SEQ ID NOS: 98 and 165), and SERPTNH1_51 (SEQ ID NOS: 101 and 168), and drug carrier comprising a mixture of a retinoid and a lipid vesicle, and methods of using these pharmaceutical compositions to treat a disease associated with hsp47 espresssion, including fibrosis.
