Fraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e.V.;Rheinisch-Westfaelische Technische Hochschule Aachen;FRIEDRICH-ALEXANDER-UNIVERSITÄT ERLANGEN- NÜRNBERG
发明人:
Christoph Stein,Radoslav Mladenov,Bernhard Stockmeyer,Stefan Barth,Lea Christin Hein,Rainer Fischer
申请号：
US15560770
公开号：
US20180050102A1
申请日:
2015.03.25
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Complexes suitable for targeting and killing a human target cell comprising a first polypeptide with a binding structure for binding the complex to the cellular surface receptor CD89 (e.g. with an anti CD89 antibody) presented on the cell surface of the human target cell and a second polypeptide comprising a toxic effector domain, preferably Pseudomonas exotoxin A)； to nucleic acid molecules encoding said complexes, vectors, host cells containing the nucleic acids and methods for preparation and producing such complexes； compositions and methods for using said complexes for the treatment of diseases, in particular of cancer diseases like leukemia.
