Non-invasive blood pressure monitoring systems and methods provide continuous, "beat-to-beat" measures of blood pressure without the need for an inflatable cuff, and/or without the need for calibration of the system or method for a particular subject using a separate blood pressure measurement system. Embodiments include various wrist-worn blood pressure monitoring devices adapted to be worn on the wrist comfortably and obtain a blood pressure measurement of the radial artery that traverses the wrist. Other implementations are adapted to measure blood pressure in a variety of other blood vessels in the body, such as the carotid artery and the templar artery, to name just two of many examples. This document describes additional designs of micro-motion sensing systems for use in such non-invasive blood pressure monitoring systems and methods.