Schaeffer, Darin G.,Reyes, Priscilla T.,Moore, William F.,Ruane, Patrick H.
申请号：
AU2007225180
公开号：
AU2007225180B2
申请日:
2007.03.12
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
This disclosure relates to implantable medical devices coated with a taxane therapeuticagent, such as paclitaxel, in one or more solid form(s) having varying dissolutionrates. Particularly preferred coatings comprise amorphous and/or solvatedsolid forms of taxane therapeutic agents that provide durable coatings thatrelease the taxane over a desired period of time, which can be varied in the absenceof a polymer by selecting the type and amount of solid forms of the taxane therapeuticagent in the coating. Other preferred embodiments relate to methods of coatingmedical devices and methods of treatment. The coatings can provide a sustainedrelease of the taxane therapeutic agent within a body vessel without containinga polymer to achieve the desired rate of paclitaxel elution.
