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TRANSDERMAL PATCH
专利权人:
DAINIPPON SUMITOMO PHARMA CO.; LTD.
发明人:
MAEDA, HIROO,YAMAMOTO, KAZUMITSU,TANAKA, MASAYASU
申请号:
EP12742258
公开号:
EP2671588A4
申请日:
2012.02.01
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
The present invention relates to an external preparation for transdermal administration, which remarkably enhances the skin permeability of 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine (compound A). The adhesive preparation of the present invention has an adhesive layer formed on one surface of a support, and the adhesive layer contains (i) compound A or a physiologically acceptable acid addition salt thereof, (ii) an adhesive, (iii) lactic acid, and (iv) an additive containing a particular permeation enhancer, whereby remarkably superior skin permeability is provided.
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