Edith Mathiowitz;Bryan E. Laulicht;Sasha H. Bakhru;Solomon S. Steiner
发明人:
Sasha H. Bakhru,Bryan E. Laulicht,Edith Mathiowitz,Solomon S. Steiner
申请号：
US14238138
公开号：
US20140178479A1
申请日:
2012.04.09
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Formulations of a neuroprotective agent for parenteral administration are described herein. The formulation is in the form of a concentrated (supersaturated) solution or a concentrated suspension of microparticles. The suspension medium or the solution solvent carrier may also contain dissolved neuroprotective agent. For the supersaturated solutions, the agent is dissolved at high concentrations of at least about 1% by weight, 5% by weight, 10% by weight, 15% by weight, or 20% by weight in a solvent suitable for parenteral administration. For the concentrated suspension, the microparticles have an effective particle size from about 100 nm to about 5 microns, preferably from about 50 nm to about 3 microns, more preferably from about 10 nm to about 2 microns. The formulations described herein can be used to treat a variety of neurological diseases/disorders and/or neurological injury or trauma.
