ASSOCIATION FOR THE ADVANCEMENT OF TISSUE ENGINEERING CELL BASED TECHNOLOGIES AND THERAPIES (A4TEC)- ASSOCIACAO
发明人:
JOAO FILIPE COLARDELLE DA LUZ MANO,ANA ISABEL MORAIS NETO,CATARINA DE ALMEIDA CUSTODIO,WENLONG SONG,MARIANA BRAGA DE OLIVEIRA
申请号：
PT10596010
公开号：
PT105960A
申请日:
2010.12.07
申请国别(地区):
PT
年份:
2012
代理人:
摘要：
The present invention relates to a process for the deposition of biomaterials on surfaces involving the patterning of areas with different surface tensions at the surface of the substrates with high repellence to water, through a treatment that increases wettability, such as a treatment with ultraviolet radiation and ozone or plasma. Another aspect of the present invention relates to the substrates comprising areas with differences of surface tension, which present specific and controllable wettability properties, which are useful for the controlled deposition of solutions of biomaterials confined to the wettable regions, allowing for their individual manipulation and analysis. A third aspect of the present invention relates to the products or devices comprising biomaterials deposited on the substrates. The present process presents as an advantage the possibility of depositing independent combinations of biomaterials, such as proteins, genes, cells and culture media in independent regions of the same treated substrate, being consequently useful for the analysis of the performance of the biomaterials in various biological environments, and an added-value in the production of biomaterials in the fields of tissue engineering, regenerative medicine, cell biology, development of pharmaceutical drugs, and the monitoring of the administration of drugs and diagnosis.A PRESENTE INVENÇÃO DIZ RESPEITO A UM PROCESSO PARA A DEPOSIÇÃO DE BIOMATERIAIS EM SUPERFÍCIES ENVOLVENDO A CONFIGURAÇÃO DE ÁREAS COM DIFERENTES TENSÕES SUPERFICIAIS À SUPERFÍCIE DE SUBSTRATOS COM ELEVADA REPELÊNCIA A ÁGUA, ATRAVÉS DE TRATAMENTO QUE AUMENTE A MOLHABILIDADE, COMO POR EXEMPLO, IRRADIAÇÃO ULTRAVIOLETA E OZONO OU PLASMA. UM OUTRO ASPECTO DA PRESENTE INVENÇÃO DIZ RESPEITO AOS SUBSTRATOS COMPREENDENDO ÁREAS COM DIFERENÇAS DE TENSÃO SUPERFICIAL, QUE APRESENTAM CARACTERÍSTICAS ESPECÍFICAS E CONTROLÁVEIS DE MOLHABILIDADE, ÚTEIS PARA EFECTUAR A DEPOSIÇÃO CONTROLADA DE SOLUÇÕES DE BIOMATERIAIS, CONFINADOS
