A dual-chamber type prefilled syringe comprises a cylindrical body within which a front plug member and a middle plug member and an end plug member are hermetically fitted to form a first chamber and a second chamber. The cylindrical body (2) has an inner surface formed with a bypass (14). When the middle plug member (7) moves to a position where the bypass (14) is formed and the first chamber (9) is communicated with the second chamber (10) for the first time via the bypass (14). In this beginning state of liquid transfer (S), an inner volume (VS) of the cylindrical body (2) between a leading end (2a) of the cylindrical body (2) and a rear end (6b) of the front plug member (6) is set to be at least 60% of a volume (VC) of a second component (12). When liquid component within the second chamber flows into the first chamber and it is possible to prevent part of the liquid component from passing through the first chamber to reach a portion for attaching an injection needle at a leading end of the cylindrical body.
