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DÉRIVÉ DE SPIROCÉTAL ET EMPLOI DUDIT DÉRIVÉ AU TITRE DE MÉDICAMENT CONTRE LE DIABÈTE
专利权人:
CHUGAI SEIYAKU KABUSHIKI KAISHA
发明人:
申请号:
EP06712450.3
公开号:
EP1852439B1
申请日:
2006.01.27
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
The present invention provides a compound of Formula (I): wherein R 1 , R 2 , R 3 and R 4 are each independently selected from a hydrogen atom, an optionally substituted C 1 -C 6 alkyl group, an optionally substituted C 7 -C 14 aralkyl group and -C(=O)Rx; Rx represents an optionally substituted C 1 -C 6 alkyl group, an optionally substituted aryl group, an optionally substituted heteroaryl group, an optionally substituted C 1 -C 6 alkoxy group or -NReRf; Ar 1 represents an optionally substituted aromatic carbocyclic ring or an optionally mono-substituted aromatic heterocyclic ring; Q represents -(CH 2 ) m -(L) p - or -(L)p-(CH 2 ) m -; m represents an integer selected from 0 to 2, n represents an integer selected from 1 and 2, and p represents an integer selected from 0 and 1; L represents -O-, -S- or -NR 5 -; and A represents an optionally substituted aryl group or an optionally substituted heteroaryl group, a prodrug thereof and a pharmaceutically acceptable salt thereof, as well as a pharmaceutical preparation or pharmaceutical composition comprising such a compound.
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