The present disclosure relates generally to compositions and methods entailing one or more microbial treatments being applied to crop plants such that changes in plant gene expression and microbiome alteration are induced that stabilize the performance of the treated plant. The present disclosure allows for the use of non-GMO plants in combination with microbial agents or derivatives that signal the plant to upregulate certain gene expression. Thus, reduction of field variability, reduction of plant microbiome diversity, stabilization of plant gene expression, stabilization of yields and stabilization of harvest quality are achieved.