The present technology is directed to prodrugs and compositions for thetreatment of variousdiseases and/or disorders comprising methylphenidate, or methylphenidatederivatives,conjugated to at least one alcohol, amine, oxoacid, thiol, or derivativesthereof. In someembodiments, the conjugates further include at least one linker. The presenttechnology alsorelates to the synthesis of methylphenidate, or methylphenidate derivatives,conjugated to atleast one alcohol, amine, oxoacid, thiol, or derivatives thereof orcombinations thereof.