Method for preparing a stable controlled-release propolis colloidal dispersion system, wherein propolis is micronized and then dispersed in the solvent system, which is under stirring and consists of deionized water and either natural 1,3-propanediol or glycerol, in which deionized water hydroxypropyl-β-cyclodextrin or β-cyclodextrin has been predissolved, and as the propolis/cyclodextrin/solvents system is under intense stirring for 30-45 min, a liposomal suspension is added thereto, and stirring is performed for 1 to 4 hours under continuous measurement of the total content in polyphenols and of the encapsulation efficiency %, until the specific parameters reach the desired values so that the stirring process is ended and the colloidal system is filtrated through suitable filters, its pH is adjusted and the size of dispersed particles as well as the release rate of the polyphenols of propolis in a buffer solution at pH 7.2 and 37° C. are measured and the colloidal system is stored.
