The Arizona Board of Regents on Behalf of The University of Arizona
发明人:
Andrew P. Capaldi,James E. Hughes Hallett
申请号：
US15535019
公开号：
US20170360820A1
申请日:
2015.12.18
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Methods and compositions for activating TORC1 aggregate formation in a fungi or a parasite, wherein TORC1 aggregate formation inhibits growth of the fungi or parasite. TORC1 aggregate formation may be activated using small molecules or other agents, and said agents may be used to treat or prevent a disease or condition associated with the fungi and parasite. The agent may target Kog1 of TORC1, e.g., the agent may directly or indirectly inhibit Kog1 leading to aggregation of the TORC1 complex.
