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METHODS FOR TREATING OVARIAN CANCER USING CONJUGATED PRODUCT
专利权人:
АНГИОКЕМ ИНК. (CA)
发明人:
КАСТАН Жан-Поль (CA),ДЕМОЛЕ Мишель (CA),ЛОУРЕНС Бетти (CA)
申请号:
RU2011146654/15
公开号:
RU2011146654A
申请日:
2010.04.20
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. A method of treating a patient with a malignant tumor that originates from the ovary, said method comprising administering to said patient an effective amount of a conjugate comprising: (a) an antitumor agent; and (b) a polypeptide comprising an amino acid sequence at least 80% identical to TFFYGGSRGKRNNFKTEEY (SEQ ID NO: 97), wherein said polypeptide is conjugated to said antitumor agent. 2. The method according to claim 1, wherein the antitumor agent is selected from the group consisting of paclitaxel, vinblastine, vincristine, etoposide, doxorubicin cyclophosphamide, taxotere, melphalan and chlorambucil. The method according to claim 2, wherein said antitumor agent is paclitaxel. The method according to any one of claims 1 to 3, wherein said polypeptide contains an amino acid sequence that is at least 90% identical to the sequence of SEQ ID NO: 97.5. The method of claim 4, wherein said polypeptide comprises the amino acid sequence of SEQ ID NO: 97.6. The method of claim 5, wherein said polypeptide consists of the amino acid sequence of SEQ ID NO: 97.7. The method according to claim 1, wherein said conjugate is administered in a dose of 100 mg / mi 2000 mg / m. The method according to claim 7, wherein said conjugate is administered at a dose of 300 mg / mdo to 1000 mg / m. The method of claim 1, wherein said conjugate is administered intravenously. The method according to claim 1, in which the specified malignant tumor metastasizes at least one place outside the ovary and the method is effective in the treatment of these metastases. The method of claim 10, wherein said cancer has metastasized to at least one place outside the brain of said patient. Method according1. Способ лечения пациента со злокачественной опухолью, которая происходит из яичника, указанный способ включает введение указанному пациенту эффективного количества конъюгата, содержащего:(а) противоопухолевое средство; и(б) полипептид, содержащий аминокислотную последовательность, по крайней мере, н
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