A motion sickness estimation device includes: a line-of-sight oscillation detector to detect oscillation of a line of sight of an occupant by using an imaging device; an object oscillation detector to detect oscillation of an object located in the line of sight; an oscillation comparator to calculate an oscillation difference from the oscillation of the line of sight and the oscillation of the object; and a motion sickness determiner to determine, on a basis of the oscillation difference, whether the occupant is in a motion sickness state.