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Utilisation d'un anticorps dirigé contre BAFF soluble dans le traitement du cancer
专利权人:
TOPOTARGET SWITZERLAND SA;BIOGEN IDEC MA INC.
发明人:
申请号:
EP03018879.1
公开号:
EP1415659B9
申请日:
2000.01.25
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
Stimulating B-cell growth, immunoglobulin production, or dendritic cell-induced B-cell growth and maturation, or co-stimulating B-cell growth and immunoglobulin production, comprising administering a composition containing the tumor necrosis factor family B cell activating factor (BAFF) or its active fragment, and optionally an anti-Micro antibody, a CD40 ligand or an anti-CD40 ligand, is new. An independent claim is also included for a method of inhibiting B-cell growth, immunoglobulin production, or dendritic cell-induced B-cell growth, or co-inhibiting B-cell growth and immunoglobulin production, comprising administering an anti-BAFF ligand molecule, a recombinant, inoperative BAFF ligand molecule, an antibody specific for BAFF ligand, active fragments of the molecules, or an antibody specific for BAFF ligand receptor, or an epitope of it. ACTIVITY : Immunosuppressive; virucide; antiinflammatory; hypotensive; nephrotropic; cardiant; cytostatic. No biological data is given. MECHANISM OF ACTION : B-cell growth and/or immunoglobulin production stimulators or inhibitors.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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