Jin-Won Youn,Ji-Sun Kwon,Jung-Soon Yoon,Yeon-Jung Kim
申请号:
US13666467
公开号:
US08685409B2
申请日:
2012.11.01
申请国别(地区):
US
年份:
2014
代理人:
摘要:
There is provided a T cell-based universal influenza vaccine including internal genes capable of preparing against infection by broad hetero-subtypic influenza viruses, and thereby preparing for unpredictable epidemic influenza. The present invention selected internal genes of the consensus sequence obtained from bird, pig, and human influenza isolates in order to develop the T cell-based universal flu vaccine. The T cell-based universal flu vaccine according to the present invention is characterized by including at least one CTL epitope, by containing a plurality of internal genes and using the entire sequence of the internal gene itself. The T cell-based universal flu vaccine can achieve broad defense in infection with hetero-subtypic influenza viruses.